Article
Clinical Evaluation of Cisplatin Sensitivity of Germline Polymorphisms in Neoadjuvant Chemotherapy for Urothelial Cancer.
Clinical genitourinary cancer - 1 Dec 2016
O'Donnell Peter H, Alanee Shaheen, Stratton Kelly L, Garcia-Grossman Ilana R, Cao Hongyuan, Ostrovnaya Irina, Plimack Elizabeth R, Manschreck Christopher, Ganshert Cory, Smith Norm D, Steinberg Gary D, Vijai Joseph, Offit Kenneth, Stadler Walter M, Bajorin Dean F
Abstract excerpt
BACKGROUND: Level 1 evidence has demonstrated increased overall survival with cisplatin-based neoadjuvant chemotherapy for patients with muscle-invasive urothelial cancer. Usage remains low, however, in part because neoadjuvant chemotherapy will not be effective for every patient. To identify the patients most likely to benefit, we evaluated germline pharmacogenomic markers for association with neoadjuvant...
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