Article
Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy.
Pharmacogenomics - 1 Apr 2020
Rumiato Enrica, Boldrin Elisa, Malacrida Sandro, Battaglia Giorgio, Sileni Vanna Chiarion, Ruol Alberto, Amadori Alberto, Saggioro Daniela
Abstract excerpt
Aim: Clinical features of esophageal cancer (EC) patients have poor prognostic power. Thus, it is paramount to discover biomarkers that can allow a more accurate survival prediction. Methods: To detect genetic variants associated with survival, DNA from 120 patients treated with cisplatin-based neoadjuvant therapy were genotyped using drug metabolism enzymes and transporters array. Results: We identified two...
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