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Article

Melanoma genome evolution across species.

BMC genomics - 7 Feb 2017

Kansler Emily R, Verma Akanksha, Langdon Erin M, Simon-Vermot Theresa, Yin Alexandra, Lee William, Attiyeh Marc, Elemento Olivier, White Richard M

Abstract excerpt

BACKGROUND: Cancer genomes evolve in both space and time, which contributes to the genetic heterogeneity that underlies tumor progression and drug resistance. In human melanoma, identifying mechanistically important events in tumor evolution is hampered due to the high background mutation rate from ultraviolet (UV) light. Cross-species oncogenomics is a powerful tool for identifying these core events, in which...

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Source

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Identifiers

PMID: 28173755
DOI: 10.1186/s12864-017-3518-8
PMCID: PMC5297047

Genes

BRAF
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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