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Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma

21 Jan 2019

Abstract excerpt

Mucosal melanoma is a rare and poorly characterized subtype of human melanoma. Here we perform a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases from mucosal sites. Analysis of these data reveals recurrently mutated driver genes shared between species such as NRAS, FAT4, PTPRJ, TP53 and PTEN, and pathogenic...

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PMID: 30664638
DOI: 10.1038/s41467-018-08081-1

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