Article
Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion.
Molecular carcinogenesis - 1 Jan 2008
Fenton Jenifer I, Lavigne Jackie A, Perkins Susan N, Liu Huaitian, Chandramouli Gadisetti V R, Shih Joanna H, Hord Norman G, Hursting Stephen D
Abstract excerpt
The imbalance in systemic mediators of inflammation, such as leptin, is thought to be involved in obesity-associated cancers. In addition, systemic endocrine signals can influence the local autocrine/paracrine factors produced within this microenvironment to influence epithelial cell fate. We previously demonstrated that leptin preferentially promotes the survival and proliferation of colon epithelial cells...
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