Article
Comprehensive mapping of antigen specific T cell responses in hepatitis C virus infected patients with or without spontaneous viral clearance.
PloS one - 1 Jan 2017
Zhang Chao, Hua Rui, Cui Yuanyuan, Wang Shasha, Yan Hongqing, Li Dongmei, Zhang Yonghong, Tu Zhengkun, Hao Pei, Chen Xinyue, Zhong Jin, Niu Junqi, Jin Xia
Abstract excerpt
Elucidating protective immunity against HCV is important for the development of a preventative vaccine. We hypothesize that spontaneous resolution of acute HCV infection offers clue to protective immune responses, and that DAA therapy affects the quality and quantity of HCV-specific T cell responses. To test these hypotheses, we performed T cell epitope mapping in 111 HCV-infected individuals including 61...
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