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Article

Tracking virus-specific CD4+ T cells during and after acute hepatitis C virus infection.

PloS one - 25 Jul 2007

Lucas Michaela, Ulsenheimer Axel, Pfafferot Katja, Heeg Malte H J, Gaudieri Silvana, Grüner Norbert, Rauch Andri, Gerlach J Tilman, Jung Maria-Christina, Zachoval Reinhart, Pape Gerd R, Schraut Winfried, Santantonio Teresa, Nitschko Hans, Obermeier Martin, Phillips Rodney, Scriba Thomas J, Semmo Nasser, Day Cheryl, Weber Jonathan N, Fidler Sarah, Thimme Robert, Haberstroh Anita, Baumert Thomas F, Klenerman Paul, Diepolder Helmut M

Abstract excerpt

BACKGROUND: CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays. ME...

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Source

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Identifiers

PMID: 17653276
DOI: 10.1371/journal.pone.0000649
PMCID: PMC1920556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17653276-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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