Article
Cytochemical flow analysis of intracellular G6PD and aggregate analysis of mosaic G6PD expression.
European journal of haematology - 1 Mar 2018
Kalnoky Michael, Bancone Germana, Kahn Maria, Chu Cindy S, Chowwiwat Nongnud, Wilaisrisak Pornpimon, Pal Sampa, LaRue Nicole, Leader Brandon, Nosten Francois, Domingo Gonzalo J
Abstract excerpt
BACKGROUND: Medicines that exert oxidative pressure on red blood cells (RBC) can cause severe hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Due to X-chromosome inactivation, females heterozygous for G6PD with 1 allele encoding a G6PD-deficient protein and the other a normal protein produce 2 RBC populations each expressing exclusively 1 allele. The G6PD mosaic is not captured...
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