Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality.

doi:10.1016/j.jpsychires.2010.02.006

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Article

Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality.

Journal of psychiatric research - 1 Oct 2010

Hohoff Christa, Mullings Emma L, Heatherley Sue V, Freitag Christine M, Neumann Lisa C, Domschke Katharina, Krakowitzky Petra, Rothermundt Matthias, Keck Martin E, Erhardt Angelika, Unschuld Paul G, Jacob Christian, Fritze Jürgen, Bandelow Borwin, Maier Wolfgang, Holsboer Florian, Rogers Peter J, Deckert Jürgen

Abstract excerpt

Adenosine A(2A) receptors are suggested to play an important role in different brain circuits and pathways involved in anxiety reactions. A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia. These multiple effects may mirror a more general...

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PMID: 20334879
DOI: 10.1016/j.jpsychires.2010.02.006

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