Article
A proteogenomic approach for protein-level evidence of genomic variants in cancer cells.
Scientific reports - 13 Oct 2016
Yeom Jeonghun, Kabir Mohammad Humayun, Lim Byungho, Ahn Hee-Sung, Kim Seon-Young, Lee Cheolju
Abstract excerpt
Variations in protein coding sequence may sometimes play important roles in cancer development. However, since variants may not express into proteins due to various cellular quality control systems, it is important to get protein-level evidence of the genomic variations. We present a proteogenomic strategy getting protein-level evidence of genomic variants, which we call sequential targeted LC-MS/MS based on...
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