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Article

High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform.

Stem cell reports - 8 Nov 2016

Nierode Gregory J, Perea Brian C, McFarland Sean K, Pascoal Jorge F, Clark Douglas S, Schaffer David V, Dordick Jonathan S

Abstract excerpt

A 3D cell culture chip was used for high-throughput screening of a human neural progenitor cell line. The differential toxicity of 24 compounds was determined on undifferentiated and differentiating NPCs. Five compounds led to significant differences in IC50 values between undifferentiated and differentiating cultures. This platform has potential use in phenotypic screening to elucidate molecular toxicology on...

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Identifiers

PMID: 28157485
DOI: 10.1016/j.stemcr.2016.10.001
PMCID: PMC5106528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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