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Article

Multi-parametric profiling network based on gene expression and phenotype data: a novel approach to developmental neurotoxicity testing.

International journal of molecular sciences - 1 Jan 2012

Nagano Reiko, Akanuma Hiromi, Qin Xian-Yang, Imanishi Satoshi, Toyoshiba Hiroyoshi, Yoshinaga Jun, Ohsako Seiichiroh, Sone Hideko

Abstract excerpt

The establishment of more efficient approaches for developmental neurotoxicity testing (DNT) has been an emerging issue for children's environmental health. Here we describe a systematic approach for DNT using the neuronal differentiation of mouse embryonic stem cells (mESCs) as a model of fetal programming. During embryoid body (EB) formation, mESCs were exposed to 12 chemicals for 24 h and then global gene...

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Identifiers

PMID: 22312247
DOI: 10.3390/ijms13010187
PMCID: PMC3269681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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