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Article

Compound selection for in vitro modeling of developmental neurotoxicity.

Frontiers in bioscience (Landmark edition) - 1 Jun 2012

Kadereit Suzanne, Zimmer Bastian, van Thriel Christoph, Hengstler Jan G, Leist Marcel

Abstract excerpt

Development of in vitro systems, such as those based on embryonic stem cell differentiation, depends on the selection of adequate test and training compounds. We recommend the use of two classes of positive controls, the "gold standard compounds" for which developmental neurotoxicity (DNT) has been proven in man, and the "pathway compounds" that are known to disrupt signalling pathways and key processes relevant...

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PMID: 22652791
DOI: 10.2741/4064

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