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Article

Phenotypic Screening of Drug Library in Actively Differentiating Mouse Embryonic Stem Cells.

Journal of biomolecular screening - 1 Apr 2016

Billard Bénédicte, Chang Chih-Ning, Singh Arun J, Gross Michael K, Allen Robert, Kioussi Chrissa

Abstract excerpt

Phenotypic screening enables the discovery of new drug leads with novel targets. ES cells differentiate into different lineages by successively making use of different subsets of the genome's possible macromolecular interactions. If a compound effectively targets just one of these interactions, it derails the developmental pathway to produce a phenotypical change. The OTRADI microsource spectrum library of 2000...

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PMID: 26746584
DOI: 10.1177/1087057115624093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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