Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis.

Assay and drug development technologies - 1 Sept 2016

Sirenko Oksana, Hancock Michael K, Hesley Jayne, Hong Dihui, Cohen Avrum, Gentry Jason, Carlson Coby B, Mann David A

Abstract excerpt

Cell models are becoming more complex to better mimic the in vivo environment and provide greater predictivity for compound efficacy and toxicity. There is an increasing interest in exploring the use of three-dimensional (3D) spheroids for modeling developmental and tissue biology with the goal of accelerating translational research in these areas. Accordingly, the development of high-throughput quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Cytotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Hepatocytes

Share to Imaging, Three-Dimensional

Share to Induced Pluripotent Stem Cells

Share to Microscopy, Confocal

Share to Spheroids, Cellular

Source

Open in PubMed Open full text

Identifiers

PMID: 27494736
DOI: 10.1089/adt.2016.729
PMCID: PMC5003004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis.PMID 27494736Read ↗

Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysisSemantic proximity Read ↗

Human iPSC-Derived 3D Hepatic Organoids in a Miniaturized Dynamic Culture SystemSemantic proximity Read ↗

Phenotypic Assays for Characterizing Compound Effects on Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.Semantic proximity Read ↗

Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for<i>In Vitro</i>Toxicity TestingSemantic proximity Read ↗

Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studiesSemantic proximity Read ↗

Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screeningSemantic proximity Read ↗

Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assaysSemantic proximity Read ↗

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.Semantic proximity Read ↗

A human liver organoid screening platform for DILI risk predictionSemantic proximity Read ↗

Three-Dimensional Liver Culture Systems to Maintain Primary Hepatic Properties for Toxicological Analysis In VitroSemantic proximity Read ↗

A Human Liver Organoid Screening Platform for DILI Risk PredictionSemantic proximity Read ↗

Toxicogenomics of drug induced liver injury – from mechanistic understanding to early prediction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.