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Towards in vitro DT/DNT testing: Assaying chemical susceptibility in early differentiating NT2 cells.

Toxicology - 2 Dec 2015

Menzner Ann-Katrin, Abolpour Mofrad Sepideh, Friedrich Oliver, Gilbert Daniel F

Abstract excerpt

Human pluripotent embryonal carcinoma (NT2) cells are increasingly considered as a suitable model for in vitro toxicity testing, e.g. developmental toxicity and neurotoxicity (DT/DNT) studies, as they undergo neuronal differentiation upon stimulation with retinoic acid (RA) and permit toxicity testing at different stages of maturation. NT2 cells have recently been reported to show specific changes in dielectric...

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PMID: 26498558
DOI: 10.1016/j.tox.2015.10.007

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