Article
Genetic variation in putative regulatory loci controlling gene expression in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 16 May 2006
Kristensen Vessela N, Edvardsen Hege, Tsalenko Anya, Nordgard Silje H, Sørlie Therese, Sharan Roded, Vailaya Aditya, Ben-Dor Amir, Lønning Per Eystein, Lien Sigbjørn, Omholt Stig, Syvänen Ann-Christine, Yakhini Zohar, Børresen-Dale Anne-Lise
Abstract excerpt
Candidate single-nucleotide polymorphisms (SNPs) were analyzed for associations to an unselected whole genome pool of tumor mRNA transcripts in 50 unrelated patients with breast cancer. SNPs were selected from 203 candidate genes of the reactive oxygen species pathway. We describe a general statistical framework for the simultaneous analysis of gene expression data and SNP genotype data measured for the same...
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