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Article

Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma.

BMC cancer - 31 Jan 2017

Hur Hoon, Ham In-Hye, Lee Dakeun, Jin Hyejin, Aguilera Kristina Y, Oh Hye Jeong, Han Sang-Uk, Kwon Ji Eun, Kim Young-Bae, Ding Ke, Brekken Rolf A

Abstract excerpt

BACKGROUND: Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that utilizes collagen as a ligand, is a key molecule in the progression of solid tumors as it regulates the interaction of cancer cells with the tumor stroma. However, the clinical relevance of DDR1 expression in gastric carcinoma is yet to be investigated. Here, we assessed the role of DDR1 in mediating the aggressive phenotype of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28143619
DOI: 10.1186/s12885-017-3051-9
PMCID: PMC5286810

Genes

DDR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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