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DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6

9 Feb 2022

Abstract excerpt

Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase family, and its ligand is collagen. Previous studies demonstrated that DDR1 is highly expressed in many tumors. However, its role in hepatocellular carcinoma (HCC) remains obscure. In this study, we found that DDR1 was upregulated in HCC tissues, and the expression of DDR1 in TNM stage II-IV was higher than that in TNM stage I in HCC...

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PMID: 35140331
DOI: 10.1038/s41388-022-02212-1

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