Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin

Abstract excerpt

Aristolochic acids I and II (AA-I/II) are carcinogenic principles of Aristolochia plants, which have been employed in traditional medicinal practices and discovered as food contaminants. While the deleterious effects of AAs are broadly acknowledged, there is a dearth of information to define the mechanisms underlying their carcinogenicity. Following bioactivation in the liver, N -hydroxyaristolactam and N...

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