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Article

Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies.

Journal of medical virology - 1 Jun 2018

Grandal Marta, Pernas Berta, Tabernilla Andrés, Mariño Ana, Álvarez Hortensia, Valcarce Nieves, Mena Alvaro, Castro-Iglesias Angeles, Pérez Ana B, Delgado Manuel, Poveda Eva

Abstract excerpt

The presence of resistance-associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV resistance at NS5A region is mainly focused on patients with hepatitis C virus (HCV) genotypes 1a (G1a) and 3 (G3) with other factors of poor treatment response (ie cirrhosis, prior treatment-exposure, or HCV-RNA >800 000 IU/mL). Herein, we evaluated in a cohort of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29427437
DOI: 10.1002/jmv.25048

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