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Article

A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria.

Scientific reports - 31 Jan 2017

Marquet Sandrine, Conte Ianina, Poudiougou Belco, Argiro Laurent, Dessein Hélia, Couturier Charlène, Burté Florence, Oumar Aboubacar A, Brown Biobele J, Traore Abdoualye, Afolabi Nathaniel K, Barry Abdoulaye, Omokhodion Samuel, Shokunbi Wuraola A, Sodeinde Olugbemiro, Doumbo Ogobara, Fernandez-Reyes Delmiro, Dessein Alain J

Abstract excerpt

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection. This encephalopathy is characterized by coma and is thought to result from mechanical microvessel obstruction and an excessive activation of immune cells leading to pathological inflammation and blood-brain barrier alterations. IL-22 contributes to both chronic inflammatory and infectious diseases, and may have protective or...

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PMID: 28139719
DOI: 10.1038/srep41636
PMCID: PMC5282577

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Source receipt: pubmed, retrieved 6 Sept 2026.

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