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Article

Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump.

The Journal of antimicrobial chemotherapy - 1 May 2017

Massip Clémence, Descours Ghislaine, Ginevra Christophe, Doublet Patricia, Jarraud Sophie, Gilbert Christophe

Abstract excerpt

Objectives: A previous study on 12 in vitro -selected azithromycin-resistant Legionella pneumophila lineages showed that ribosomal mutations were major macrolide resistance determinants. In addition to these mechanisms that have been well described in many species, mutations upstream of lpeAB operon, homologous to acrAB in Escherichia coli , were identified in two lineages. In this study, we investigated the role...

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Share to Azithromycin
Share to Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Ribosomal, 23S

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Identifiers

PMID: 28137939
DOI: 10.1093/jac/dkw594

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