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Article

Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa.

Nature communications - 16 Oct 2024

Goltermann Lise, Laborda Pablo, Irazoqui Oihane, Pogrebnyakov Ivan, Bendixen Maria Pals, Molin Søren, Johansen Helle Krogh, La Rosa Ruggero

Abstract excerpt

Macrolides are widely used antibiotics for the treatment of bacterial airway infections. Due to its elevated minimum inhibitory concentration in standardized culture media, Pseudomonas aeruginosa is considered intrinsically resistant and, therefore, antibiotic susceptibility testing against macrolides is not performed. Nevertheless, due to macrolides' immunomodulatory effect and suppression of virulence factors,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39414850
DOI: 10.1038/s41467-024-53329-8
PMCID: PMC11484784

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