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Article

Creatine maintains intestinal homeostasis and protects against colitis

30 Jan 2017

Abstract excerpt

Significance The present study used a forward genetic approach to identify new causative mutations in an environmentally sensitized screen for colitis. A candidate mutation in Gatm , verified by CRISPR/Cas9 targeting, demonstrated the need for rapid replenishment of cytoplasmic ATP within colonic epithelial cells to restore barrier integrity. This environmentally specified requirement for energy to avert colitis...

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Identifiers

PMID: 28137860
DOI: 10.1073/pnas.1621400114

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