Article

Investigation of the creatine biosynthesis negative feedback loop via creatine mediated control of arginine:glycine amidinotransferase expression in human HAP1 cells implies an intracellular creatine sensing mechanism

2023-09-08

Abstract excerpt

Cellular homeostasis of creatine (CT), integral part of the energy buffering and -transducing system connecting intracellular sites of ATP production and -utilization, comprises of mechanisms that increase CT, i.e., biosynthesis and cellular uptake, and CT-lowering processes, such as export and non-enzymatic conversion to creatinine. The negative feedback loop by which CT controls its biosynthesis via suppression...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 573fa001-3ada-5cdd-ba0c-e0024be552bb
DOI: 10.21203/rs.3.rs-3253350/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigation of the creatine biosynthesis negative feedback loop via creatine mediated control of arginine:glycine amidinotransferase expression in human HAP1 cells implies an intracellular creatine sensing mechanismDOI 10.21203/rs.3.rs-3253350/v1Read

Creatine biosynthesis and transport in health and disease.Semantic proximity Read

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophySemantic proximity Read

Creatine Effects on Kidney Tissues and Renal Function: New Insights from a Bioinformatic StudySemantic proximity Read

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.Semantic proximity Read

Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activitySemantic proximity Read

Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictionsSemantic proximity Read

The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency SyndromeSemantic proximity Read

Genetic Determinants of Creatine Bioavailability and Responsiveness: Emphasis on Common Low-Impact Variants.Semantic proximity Read

The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter.Semantic proximity Read

Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans.Semantic proximity Read

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levelsSemantic proximity Read

L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome.Semantic proximity Read