Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing new fluorescent tools for studying 5-HT₃ receptor pharmacology.

Neuropharmacology - 1 Mar 2015

Jack Thomas, Simonin Jonathan, Ruepp Marc-David, Thompson Andrew J, Gertsch Jürg, Lochner Martin

Abstract excerpt

The pharmacological characterization of ligands depends upon the ability to accurately measure their binding properties. Fluorescence provides an alternative to more traditional approaches such as radioligand binding. Here we describe the binding and spectroscopic properties of eight fluorescent 5-HT3 receptor ligands. These were tested on purified receptors, expressed receptors on live cells, or in vivo. All...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Fluorescence Polarization
Share to Fluorescent Dyes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intestinal Mucosa

Share to Molecular Structure

Share to Radioligand Assay

Share to Receptors, Serotonin, 5-HT3

Share to Salivary Glands

Source

Identifiers

PMID: 25460187
DOI: 10.1016/j.neuropharm.2014.11.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing new fluorescent tools for studying 5-HT₃ receptor pharmacology.PMID 25460187Read ↗

A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.Semantic proximity Read ↗

The binding orientations of structurally-related ligands can differ; A cautionary note.Semantic proximity Read ↗

Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.Semantic proximity Read ↗

Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP.Semantic proximity Read ↗

Interactions of granisetron with an agonist-free 5-HT3A receptor model.Semantic proximity Read ↗

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.Semantic proximity Read ↗

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor.Semantic proximity Read ↗

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.Semantic proximity Read ↗

5-HT3 receptors: potential of individual isoforms for personalised therapySemantic proximity Read ↗

High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor.Semantic proximity Read ↗

The C and E subunits of the serotonin 5-HT3 receptor subtly modulate electrical properties of the receptor.Semantic proximity Read ↗

Characterization of 5-HT3 receptor mutations identified in schizophrenic patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.