The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

doi:10.1002/hep.29089

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Article

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

Hepatology (Baltimore, Md.) - 1 Aug 2017

von Loeffelholz Christian, Lieske Stefanie, Neuschäfer-Rube Frank, Willmes Diana M, Raschzok Nathanael, Sauer Igor M, König Jörg, Fromm Martin F, Horn Paul, Chatzigeorgiou Antonios, Pathe-Neuschäfer-Rube Andrea, Jordan Jens, Pfeiffer Andreas F H, Mingrone Geltrude, Bornstein Stefan R, Stroehle Peter, Harms Christoph, Wunderlich F Thomas, Helfand Stephen L, Bernier Michel, de Cabo Rafael, Shulman Gerald I, Chavakis Triantafyllos, Püschel Gerhard P, Birkenfeld Andreas L

Abstract excerpt

Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling...

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PMID: 28133767
DOI: 10.1002/hep.29089
PMCID: PMC5519435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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