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Article

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood-brain barrier.

The Biochemical journal - 12 Feb 2021

Kopel Jonathan J, Bhutia Yangzom D, Sivaprakasam Sathish, Ganapathy Vadivel

Abstract excerpt

NaCT/SLC13A5 is a Na+-coupled transporter for citrate in hepatocytes, neurons, and testes. It is also called mINDY (mammalian ortholog of 'I'm Not Dead Yet' in Drosophila). Deletion of Slc13a5 in mice leads to an advantageous phenotype, protecting against diet-induced obesity, and diabetes. In contrast, loss-of-function mutations in SLC13A5 in humans cause a severe disease, EIEE25/DEE25 (early infantile epileptic...

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PMID: 33544126
DOI: 10.1042/BCJ20200877
PMCID: PMC7868109

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