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Brucella abortus 2308ΔNodVΔNodW double-mutant is highly attenuated and confers protection against wild-type challenge in BALB/c mice.

Microbial pathogenesis - 1 May 2017

Li Zhiqiang, Wang Shuli, Zhang Jinliang, Yang Guangli, Yuan Baodong, Huang Jie, Han Jincheng, Xi Li, Xiao Yanren, Chen Chuangfu, Zhang Hui

Abstract excerpt

Brucellosis is an important zoonotic disease of worldwide distribution, which causes animal and human disease. However, the current Brucella abortus (B. abortus) vaccines (S19 and RB51) have several drawbacks, including residual virulence for animals and humans. Moreover, S19 cannot allow serological differentiation between infected and vaccinated animals. We constructed double deletion (ΔNodVΔNodW) mutant from...

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PMID: 28131952
DOI: 10.1016/j.micpath.2017.01.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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