Article
A potent Brucella abortus 2308 Δery live vaccine allows for the differentiation between natural and vaccinated infection.
Journal of microbiology (Seoul, Korea) - 1 Aug 2014
Zhang Junbo, Yin Shuanghong, Guo Fei, Meng Ren, Chen Chuangfu, Zhang Hui, Li Zhiqiang, Fu Qiang, Shi Huijun, Hu Shengwei, Ni Wei, Li Tiansen, Zhang Ke
Abstract excerpt
Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. However, the current Brucella abortus vaccines (S19 and RB51) are deficient; they can cause abortion in pregnant animals. Moreover, when the vaccine S19 is used, tests cannot differentiate natural from vaccinated infection. Therefore, a safer and more potent vaccine is needed. A Brucella abortus 2308 ery promoter mutant...
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