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Article

Brucella abortus S19 rfbD mutant is highly attenuated, DIVA enable and confers protection against virulent challenge in mice.

Biologicals : journal of the International Association of Biological Standardization - 1 Jan 2020

Lalsiamthara Jonathan, Kaur Gurpreet, Gogia Neha, Ali Syed Atif, Goswami Tapas Kumar, Chaudhuri Pallab

Abstract excerpt

Brucella abortus S19 is an important tool for controlling bovine brucellosis across the globe. However, vaccination with S19 suffers critical shortcomings such as, presence of residual virulence, induction of abortion and sero-diagnostic interference. In this study, rfbD gene deleted mutant S19 was developed. The mutant strain designated S19ΔR displayed rough LPS phenotype, which was confirmed by acriflavine...

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PMID: 31843357
DOI: 10.1016/j.biologicals.2019.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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