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[Construction of Brucella abortus A19-delta VirB12 mutant and evaluation of its protective efficacy against 2308 strain challenge in BALB/c mice].

Wei sheng wu xue bao = Acta microbiologica Sinica - 4 Nov 2013

Yi Xinping, Ye Feng, Yao Gang, Gu Wenxi, Ma Xiaojing, Wu Dongling, Zhong Qi

Abstract excerpt

OBJECTIVE: A19-deltaVirB12 deletion mutant of Brucella abortus was constructed by using homologous recombination technology. BALB/c mice were vaccinated intraperitoneally with the mutant to evaluate protective efficacy against Brucella abortus 2308 challenge. METHOD: A SacB gene was amplified by PCR from pIB279 plasmid. The sequences upstream and downstream of the VirB12 gene were amplified by PCR from Brucella...

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PMID: 24617263

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