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Article

Prediction of functional loss of human angiogenin mutants associated with ALS by molecular dynamics simulations.

Scientific reports - 1 Jan 2013

Padhi Aditya K, Jayaram Bhyravabhotla, Gomes James

Abstract excerpt

Several missense mutations in the coding region of angiogenin (ANG) gene have been identified in Amyotrophic Lateral Sclerosis (ALS) patients. These mutations lead to loss of either ribonucleolytic activity or nuclear translocation activity or both of ANG (protein encoded by ANG gene) causing ALS. We present here a cohesive and comprehensive picture of the molecular origins of functional loss of all ALS...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Mutation, Missense

Share to Nuclear Localization Signals

Share to Protein Conformation

Share to Ribonuclease, Pancreatic

Source

Open in PubMed Open full text

Identifiers

PMID: 23393617
DOI: 10.1038/srep01225
PMCID: PMC3566597

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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