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Article

Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.

Scientific reports - 8 Feb 2017

Bradshaw William J, Rehman Saima, Pham Tram T K, Thiyagarajan Nethaji, Lee Rebecca L, Subramanian Vasanta, Acharya K Ravi

Abstract excerpt

Mutations in Angiogenin (ANG), a member of the Ribonuclease A superfamily (also known as RNase 5) are known to be associated with Amyotrophic Lateral Sclerosis (ALS, motor neurone disease) (sporadic and familial) and Parkinson's Disease (PD). In our previous studies we have shown that ANG is expressed in neurons during neuro-ectodermal differentiation, and that it has both neurotrophic and neuroprotective...

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Source

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Identifiers

PMID: 28176817
DOI: 10.1038/srep41996
PMCID: PMC5296752

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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