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Article

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.

Nature communications - 1 Jan 2012

Thiyagarajan Nethaji, Ferguson Ross, Subramanian Vasanta, Acharya K Ravi

Abstract excerpt

Mutations in angiogenin (ANG), a member of the ribonuclease A superfamily, are associated with amyotrophic lateral sclerosis (ALS; sporadic and familial) and Parkinson's disease. We have previously shown that ANG is expressed in neurons during neuro-ectodermal differentiation, and that it has both neurotrophic and neuroprotective functions. Here we report the atomic resolution structure of native ANG and 11...

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Source

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Identifiers

PMID: 23047679
DOI: 10.1038/ncomms2126
PMCID: PMC3493651

Genes

ANG

Provenance

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Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.PMID 23047679Read ↗

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Long-timescale atomistic simulations uncover loss-of-function mechanisms of uncharacterized Angiogenin mutants associated with ALS.Semantic proximity Read ↗

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