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Article

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system.

Science (New York, N.Y.) - 15 May 1998

Herzog K H, Chong M J, Kapsetaki M, Morgan J I, McKinnon P J

Abstract excerpt

Ataxia telangiectasia (AT) is characterized by progressive neurodegeneration that results from mutation of the ATM gene. However, neither the normal function of ATM in the nervous system nor the biological basis of the degeneration in AT is known. Resistance to apoptosis in the developing central...

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Source

Identifiers

PMID: 9582124
DOI: 10.1126/science.280.5366.1089

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9582124-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system.PMID 9582124Read ↗

Ataxia Telangiectasia Mutated-Dependent Apoptosis after Genotoxic Stress in the Developing Nervous System Is Determined by Cellular Differentiation StatusSemantic proximity Read ↗

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.Semantic proximity Read ↗

Contribution of the Atm Protein to Maintaining Cellular Homeostasis Evidenced by Continuous Activation of the AP-1 Pathway in Atm-deficient BrainsSemantic proximity Read ↗

Ataxia telangiectasia mutated is essential during adult neurogenesis.Semantic proximity Read ↗

Atm-null mice exhibit enhanced radiation-induced birth defects and a hybrid form of embryonic programmed cell death indicating a teratological suppressor function for ATM.Semantic proximity Read ↗

Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development.Semantic proximity Read ↗

Radiation-induced apoptosis in the adult central nervous system is p53-dependentSemantic proximity Read ↗

DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during NeurogenesisSemantic proximity Read ↗

Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.Semantic proximity Read ↗

Analysis of the Ataxia Telangiectasia Mutated-Mediated DNA Damage Response in Murine Cerebellar NeuronsSemantic proximity Read ↗

Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.Semantic proximity Read ↗

The role of ATM and DNA damage in neurons: upstream and downstream connections.Semantic proximity Read ↗

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