Article
Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.
Blood - 31 May 2018
Tiacci Enrico, Ladewig Erik, Schiavoni Gianluca, Penson Alex, Fortini Elisabetta, Pettirossi Valentina, Wang Yuchun, Rosseto Ariele, Venanzi Alessandra, Vlasevska Sofija, Pacini Roberta, Piattoni Simonetta, Tabarrini Alessia, Pucciarini Alessandra, Bigerna Barbara, Santi Alessia, Gianni Alessandro M, Viviani Simonetta, Cabras Antonello, Ascani Stefano, Crescenzi Barbara, Mecucci Cristina, Pasqualucci Laura, Rabadan Raul, Falini Brunangelo
Abstract excerpt
Dissecting the pathogenesis of classical Hodgkin lymphoma (cHL), a common cancer in young adults, remains challenging because of the rarity of tumor cells in involved tissues (usually <5%). Here, we analyzed the coding genome of cHL by microdissecting tumor and normal cells from 34 patient biopsies for a total of ∼50 000 singly isolated lymphoma cells. We uncovered several recurrently mutated genes, namely, STAT6...
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