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Article

Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure.

Cell reports - 24 Jan 2017

Liu Shijie, Kim Tae-Hyung, Franklin Derek A, Zhang Yanping

Abstract excerpt

The RPL11-MDM2 interaction constitutes a p53 signaling pathway activated by deregulated ribosomal biosynthesis in response to stress. Mice bearing an MDM2C305F mutation that disrupts RPL11-MDM2 binding were analyzed on a high-fat diet (HFD). The Mdm2C305F/C305F mice, although phenotypically indistinguishable from wild-type (WT) mice when fed normal chow, demonstrated decreased fat accumulation along with improved...

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Share to Adipose Tissue
Share to Diet, High-Fat
Share to Glucose Transporter Type 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-mdm2

Share to Proto-Oncogene Proteins c-myc

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Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28122227
DOI: 10.1016/j.celrep.2016.12.086
PMCID: PMC5560502

Genes

RPL11
MDM2
MYC
SIRT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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