Article
Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
JCI insight - 2 Oct 2020
Abrams Jeffrey, Roybal Daniel, Chakouri Nourdine, Katchman Alexander N, Weinberg Richard, Yang Lin, Chen Bi-Xing, Zakharov Sergey I, Hennessey Jessica A, Avula Uma Mahesh R, Diaz Johanna, Wang Chaojian, Wan Elaine Y, Pitt Geoffrey S, Ben-Johny Manu, Marx Steven O
Abstract excerpt
The Ca2+-binding protein calmodulin has emerged as a pivotal player in tuning Na+ channel function, although its impact in vivo remains to be resolved. Here, we identify the role of calmodulin and the NaV1.5 interactome in regulating late Na+ current in cardiomyocytes. We created transgenic mice with cardiac-specific expression of human NaV1.5 channels with alanine substitutions for the IQ motif (IQ/AA). The...
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