FGF12 is a candidate Brugada syndrome locus.

doi:10.1016/j.hrthm.2013.09.064

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Article

FGF12 is a candidate Brugada syndrome locus.

Heart rhythm - 1 Dec 2013

Hennessey Jessica A, Marcou Cherisse A, Wang Chuan, Wei Eric Q, Wang Chaojian, Tester David J, Torchio Margherita, Dagradi Federica, Crotti Lia, Schwartz Peter J, Ackerman Michael J, Pitt Geoffrey S

Abstract excerpt

BACKGROUND: Less than 30% of the cases of Brugada syndrome (BrS) have an identified genetic cause. Of the known BrS-susceptibility genes, loss-of-function mutations in SCN5A or CACNA1C and their auxiliary subunits are most common. On the basis of the recent demonstration that fibroblast growth factor (FGF) homologous factors (FHFs; FGF11-FGF14) regulate cardiac Na(+) and Ca(2+) channel currents, we hypothesized...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Animals
Brugada Syndrome
Cells, Cultured
Child
Chromatography, High Pressure Liquid
DNA
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Models, Animal

Electrocardiography

Female

Fibroblast Growth Factors

Humans

Immunohistochemistry

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 24096171
DOI: 10.1016/j.hrthm.2013.09.064
PMCID: PMC3870051

Genes

FGF12
FGF11
FGF14

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24096171-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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