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Article

Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Jun 2015

Puranam Ram S, He Xiao Ping, Yao Lijun, Le Tri, Jang Wonjo, Rehder Catherine W, Lewis Darrell V, McNamara James O

Abstract excerpt

We identified a family in which a translocation between chromosomes X and 14 was associated with cognitive impairment and a complex genetic disorder termed "Genetic Epilepsy and Febrile Seizures Plus" (GEFS(+)). We demonstrate that the breakpoint on the X chromosome disrupted a gene that encodes an auxiliary protein of voltage-gated Na(+) channels, fibroblast growth factor 13 (Fgf13). Female mice in which one...

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Source

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Identifiers

PMID: 26063919
DOI: 10.1523/JNEUROSCI.3470-14.2015
PMCID: PMC4461691

Genes

FGF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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