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Induction of dormancy in hypoxic human papillomavirus-positive cancer cells

23 Jan 2017

Abstract excerpt

Oncogenic human papillomaviruses (HPVs) are closely linked to major human malignancies, including cervical and head and neck cancers. It is widely assumed that HPV-positive cancer cells are under selection pressure to continuously express the viral E6/E7 oncogenes, that their intracellular p53 levels are reconstituted on E6/E7 repression, and that E6/E7 inhibition phenotypically results in cellular senescence....

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PMID: 28115701
DOI: 10.1073/pnas.1615758114

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