Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced Quiescence

10 Mar 2021

Abstract excerpt

Double strand breaks (DSBs) are highly toxic to a cell, a property that is exploited in radiation therapy. A critical component for the damage induction is cellular oxygen, making hypoxic tumor areas refractory to the efficacy of radiation treatment. During a fractionated radiation regimen, these hypoxic areas can be re-oxygenated. Nonetheless, hypoxia still constitutes a negative prognostic factor for the...

Topics

Join the communities discussing this publication.

Cancer, Hypoxia, and Metabolism
Effects of Radiation Exposure
Radiation Therapy and Dosimetry

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33801903
DOI: 10.3390/cells10030610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance of Hypoxic Cells to Ionizing Radiation Is Mediated in Part via Hypoxia-Induced QuiescencePMID 33801903Read ↗

Induction of dormancy in hypoxic human papillomavirus-positive cancer cellsSemantic proximity Read ↗

Research progress on therapeutic targeting of quiescent cancer cellsSemantic proximity Read ↗

Hypoxia Modulates Radiosensitivity and Response to Different Radiation Qualities in A549 Non-Small Cell Lung Cancer (NSCLC) CellsSemantic proximity Read ↗

HPV status and oxygen tension shape transcriptomic, inflammatory, and cell cycle responses in HNSCC treated with ionizing radiationSemantic proximity Read ↗

Comparative analyses of prolonged stress responses of breast carcinoma cells after hypofractionated irradiation <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN StatusSemantic proximity Read ↗

Ionizing radiation response of primary normal human lens epithelial cellsSemantic proximity Read ↗

Radiation-induced cellular senescence results from a slippage of long-term G<sub>2</sub>arrested cells into G<sub>1</sub>phaseSemantic proximity Read ↗

The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced SenescenceSemantic proximity Read ↗

Insights into the characteristics of primary radioresistant cervical cancer using single-cell transcriptomicsSemantic proximity Read ↗

Differential redox-mitochondrial adaptation to ultra-high dose rate irradiation in astrocytes and glioma cellsSemantic proximity Read ↗

Hypoxia-reoxygenation cycle leads to context dependent phenotypic effects in breast cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.