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Article

Atrial natriuretic peptide is negatively regulated by microRNA-425.

The Journal of clinical investigation - 1 Aug 2013

Arora Pankaj, Wu Connie, Khan Abigail May, Bloch Donald B, Davis-Dusenbery Brandi N, Ghorbani Anahita, Spagnolli Ester, Martinez Andrew, Ryan Allicia, Tainsh Laurel T, Kim Samuel, Rong Jian, Huan Tianxiao, Freedman Jane E, Levy Daniel, Miller Karen K, Hata Akiko, Del Monte Federica, Vandenwijngaert Sara, Swinnen Melissa, Janssens Stefan, Holmes Tara M, Buys Emmanuel S, Bloch Kenneth D, Newton-Cheh Christopher, Wang Thomas J

Abstract excerpt

Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3' untranslated region of NPPA, the gene encoding atrial natriuretic peptide (ANP), is associated with blood pressure. We selected individuals on the basis of rs5068 genotype (AG vs. AA) and fed them a low- or high-salt diet for...

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Source

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Identifiers

PMID: 23867623
DOI: 10.1172/JCI67383
PMCID: PMC3726159

Genes

NPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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