Article
SDHD Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma.
Cancer research - 1 Apr 2017
Zhang Tongwu, Xu Mai, Makowski Matthew M, Lee Christine, Kovacs Michael, Fang Jun, Willems Esther, Trent Jeffrey M, Hayward Nicholas K, Vermeulen Michiel, Brown Kevin M
Abstract excerpt
SDHD encodes subunit D of the succinate dehydrogenase complex, an integral membrane protein. Across cancer types, recurrent SDHD promoter mutations were reported to occur exclusively in melanomas, at a frequency of 4% to 5%. These mutations are predicted to disrupt consensus ETS transcription factor-binding sites and are correlated with both reduced SDHD gene expression and poor prognosis. However, the...
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