Article
Gab2-mediated signaling promotes melanoma metastasis.
The American journal of pathology - 1 Apr 2009
Horst Basil, Gruvberger-Saal Sofia K, Hopkins Benjamin D, Bordone Lindsey, Yang Ying, Chernoff Karen A, Uzoma Ijeoma, Schwipper Volker, Liebau Jutta, Nowak Norma J, Brunner Georg, Owens David, Rimm David L, Parsons Ramon, Celebi Julide Tok
Abstract excerpt
Metastatic melanoma is a disease with a poor prognosis that currently lacks effective treatments. Critical biological features of metastasis include acquisition of migratory competence, growth factor independence, and invasive potential. In an attempt to identify genes that contribute to melanoma pathogenesis, a genome-wide search using bacterial artificial chromosome array comparative genomic hybridization and...
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