Article
PP6C hotspot mutations in melanoma display sensitivity to Aurora kinase inhibition.
Molecular cancer research : MCR - 1 Mar 2014
Gold Heidi L, Wengrod Jordan, de Miera Eleazar Vega-Saenz, Wang Ding, Fleming Nathaniel, Sikkema Lisa, Kirchhoff Tomas, Hochman Tsivia, Goldberg Judith D, Osman Iman, Gardner Lawrence B
Abstract excerpt
UNLABELLED: Recent whole genome melanoma sequencing studies have identified recurrent mutations in the gene encoding the catalytic subunit of serine/threonine phosphatase 6 (PPP6C/PP6C). However, the biochemical, functional, and clinical ramifications of these mutations are unknown. Sequencing PP6C from patients with melanoma (233 primary and 77 metastatic specimens) with extended prospective clinical outcome...
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