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Article

PP6C hotspot mutations in melanoma display sensitivity to Aurora kinase inhibition.

Molecular cancer research : MCR - 1 Mar 2014

Gold Heidi L, Wengrod Jordan, de Miera Eleazar Vega-Saenz, Wang Ding, Fleming Nathaniel, Sikkema Lisa, Kirchhoff Tomas, Hochman Tsivia, Goldberg Judith D, Osman Iman, Gardner Lawrence B

Abstract excerpt

UNLABELLED: Recent whole genome melanoma sequencing studies have identified recurrent mutations in the gene encoding the catalytic subunit of serine/threonine phosphatase 6 (PPP6C/PP6C). However, the biochemical, functional, and clinical ramifications of these mutations are unknown. Sequencing PP...

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Source

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Identifiers

PMID: 24336958
DOI: 10.1158/1541-7786.MCR-13-0422
PMCID: PMC3962698

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24336958-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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