Article
Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene.
Molecular cell - 19 Jan 2017
Meydan Sezen, Klepacki Dorota, Karthikeyan Subbulakshmi, Margus Tõnu, Thomas Paul, Jones John E, Khan Yousuf, Briggs Joseph, Dinman Jonathan D, Vázquez-Laslop Nora, Mankin Alexander S
Abstract excerpt
Metal efflux pumps maintain ion homeostasis in the cell. The functions of the transporters are often supported by chaperone proteins, which scavenge the metal ions from the cytoplasm. Although the copper ion transporter CopA has been known in Escherichia coli, no gene for its chaperone had been identified. We show that the CopA chaperone is expressed in E. coli from the same gene that encodes the transporter....
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