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Article

Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network.

Metallomics : integrated biometal science - 1 Sept 2016

Zhu Sha, Shanbhag Vinit, Hodgkinson Victoria L, Petris Michael J

Abstract excerpt

The ATP7A protein is a ubiquitous copper-transporting P-type ATPase that is mutated in the lethal pediatric disorder of copper metabolism, Menkes disease. The steady-state location of ATP7A is within the trans-Golgi network (TGN), where it delivers copper to copper-dependent enzymes within the secretory pathway. However, ATP7A constantly cycles between the TGN and the plasma membrane, and in the presence of high...

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Identifiers

PMID: 27337370
DOI: 10.1039/c6mt00093b
PMCID: PMC5025395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network.PMID 27337370Read ↗

Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.Semantic proximity Read ↗

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network.Semantic proximity Read ↗

Mutation in the CPC motif-containing 6th transmembrane domain affects intracellular localization, trafficking and copper transport efficiency of ATP7A protein in mosaic mutant mice--an animal model of Menkes disease.Semantic proximity Read ↗

Direct interactions of adaptor protein complexes 1 and 2 with the copper transporter ATP7A mediate its anterograde and retrograde trafficking.Semantic proximity Read ↗

Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.Semantic proximity Read ↗

Translational read‐through of a nonsense mutation in <i>ATP7A</i> impacts treatment outcome in Menkes diseaseSemantic proximity Read ↗

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.Semantic proximity Read ↗

Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.Semantic proximity Read ↗

The lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites.Semantic proximity Read ↗

Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease.Semantic proximity Read ↗

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial ContentSemantic proximity Read ↗

Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess.Semantic proximity Read ↗

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